Pengaruh Ekstrak Wortel (Daucus Carota Linn.) Terhadap Aterosklerosis Pada Burung Puyuh Jantan (Cortunic-Cortunix Japonica)

Suhatri Suhatri, Hel Amir, Zet Rizal


Has done research the effect of extracts of carrot (Daucus carota Linn.) Against atherosclerosis in male quail (Cortunix-cortunix japonica). Atherosclerosis induced by administering Prophylthiouracyl (PTU) and high-fat foods (MLT). Carrot extract dose given on quail is 50 mg / kg BW, 100 mg / kg BW and 200 mg / Kg BW on quail males given orally for 60 Days. The results showed that the administration of carrot extract at a dose of 100 mg / kg BW and 200 mg / kg BW can prevent the formation of atherosclerosis in male quail, marked on the wall thickness of the aorta, the aortic lumen and extensive damage to endothelial cells was not different from the negative control (P < 0.05). Carrot extract dose of 50 mg / kg BW for 60 days can not be pried prevent its established atherosclerosis, characterized in aortic wall thickness, area of the aortic lumen and endothelial cell damage is not different from the positive control (P> 0.05).

Kata Kunci

Extracts Carrot; Atherosclerosis; Male Quail

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Casella, G., Greco, C., Perugini, E.(2006). Atheromatosis of the thoracic aorta and risk of stroke. G Ital Cardiol. 7(5):309–16.

Chatatikun, M & Chiabchalard, A. (2013). Phytochemical Screening and Free Radical Scavenging Activities of Orang Baby Carrot and Carrot ( Daucus carota Linn.) Root Crude Exstracts. J Chem Pharm Res. 5(4):97-102.

Coon, J. S. T. (2003). Herb For cholesterol reduction. J.Fam.Pract. 52.6.

David, S. J. (2010). Statistik Farmasi. Penerjemah: Harrizul Rivai, Jakarta: Penerbit EGC.

Departemen Kesehatan RI. (2008). Farmakope Herbal Indonesia. Jakarta : Departemen Kesehatan RI.

Departemen Kesehatan RI. (1986). Sediaan galenika. Jakarta : Departemen Kesehatan Republik Indonesia.

Guyton, C. A. (1997). Buku Ajar Fisiologi Kedokteran.(Edisi 9). Penerjemah: L. Setiawan. Jakarta: Penerbit buku kedokteran EGC

Kiernan, J. A. (1990). Histological and Histochemical Methods : Theory and Practice. New York: Pergamon Press, Oxford.

Leeson, C. R., Leeson, T. S., Paparo. A. A. (1989). Buku Ajar Histologi (Edisi V). Penerjemah: Staf ahli Histologi FKUI, Jakarta: Penerbit Buku Kedokteran.

Mitchell, R. N. (2006). Buku Saku Dasar Patologi Penyakit Robbins & Cotran. (Edisi 7). hal 305. Penerjemah: dr. Andry Hartono. Jakarta: Penerbit Buku Kedokteran EGC.

Patil, M. V. K., Kandhare, A. D., Bhisa, S. D. (2012). Pharmacological Evaluation of Ethanolic Extract of Daucus carota Linn Root Formulated Cream on Wound Healing Using Excision and Incision Wound Model. Asian Pasific Journal of Tropical Biomedicine.12: S646-S655.

Price, S. A. & Lorraine,W. N. (1995). Patofisiologi Konsep Klinis Proses-proses Penyakit. (Edisi 4). Penerjemah: Peter Anugraha. Jakarta: Penerbit Buku Kedokteran EGC.

Sibulesky, L. (1999). Safety of <7500 RE (<25000 IU) vitamin A daily im adults with retinitis pigmentosa. Am clin nutr . 69 (4) :656-663.

Welty, F.K. (2001). Cardiovascular disease and dyslipidemia in women. Arch Internal Medicine.161:514–22.

Vogel, H. G. (2002). Drug Discovery and Evaluation Pharmacological Assays Springer. German.



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