Karakterisasi Kompleks Inklusi Simvastatin – Β-Siklodekstrin Metoda Co-Grinding dengan Variasi Waktu Penggilingan

Maria Dona Octavia, Auzal Halim, Monica Afrinda


Characterization of simvastatin - b-cyclodextrin inclusion complexes by co-grinding method had been studied. Solid state simvastatin - b-cyclodextrin inclusion complex prepared by co-grinding method in 1:1 mol ratio. Simvastatin, b-cyclodextrin, simvastatin - b-cyclodextrin physical mixture and inclusion complexes were characterization by X-ray Diffraction (XRD), Fourier Transformation Infra red (FTIR), Differential Thermal Analysis (DTA), scanning electron microscope (SEM) and dissolution studies. X-Ray Diffraction results showed decreasing peak intensity diffractogram very sharp compared to pure simvastatin and differential thermal analysis (DTA) were showed the interaction between simvastatin and b-cyclodextrin. In vitro dissolution rate studies of simvastatin, simvastatin - b-cyclodextrin physical mixture and inclusion complexes. Simvastatin - b-cyclodextrin inclusion complex showed increasing dissolution rate significant compared to simvastatin - b-cyclodextrin physical mixture and pure simvatatin. The results showed the formation of inclusion complex between simvastatin and b-cyclodextrin by co-grinding method.

Kata Kunci

inclusion complexes; simvastatin; β-cyclodextrin dan co-grinding

Teks Lengkap:

PDF (English)


Abdou, H. M. (1989). Dissolution, Bioavaibility And Bioequivalence. Pennsylavania: Mark Publishing Company Easton.

Bekers, O., Uitjtendaal, E. V., Beijnen, J. H., Bult, A., & Undenberg, W. J. M. (1991). Cyclodextrin in pharmaceutical field. Drug Dev. Ind. Pharm, 17, (11), 1503-1549.

Challa, R., Ahuja, A., Ali, J., & Khar, R. K. (2005). Cyclodextrins in drug delivery: an updated review. AAPS PharmSciTech, 6, (2), E329-E357.

Charumanee, S. (2004). Amorphization and Dissolution Studies of Acethaminophen - -Cyclodextrin Inclusion Complexes. CMU Journal, 3, (1), 13-2.

Chaudhary, A., Nagaich, U., Gulati, N., Sharma, V., K., & Khosa, R., L. (2012). Enhancement of solubilization and bioavailability of poorly soluble drugs by physical and chemical modifications: A recent review. Journal of Advanced Pharmacy Education & Research, 2, (1), 32-6.

Colombo., G. G., & Grasi, M. (2009). Drug mechanochemical activatiaon. Journal of pharmaceutical sciences, 98, (11), 3961-3986.

Departemen Kesehatan Republik Indonesia. (2009). Suplemen I Farmakope Indonesia. (Edisi IV), Jakarta: Departemen Kesehatan Republik Indonesia.

Frank, S. G. (1975). Inclusion compound. Journal of Pharmaceutical Sciences, 64, (10), 1585-1601.

Ghorab, M. K., & Adeyeye, M., C. (2001). Enchanment of ibuprofen dissolution via wet granulation with β-cyclodextrin. Pharm. Dev. Technol, 6,(3), 303-312.

Jug, M., Becirevic, L. M., & Cetina, C., B. (2005). Influence of Cyclodextrin Complexation on Piroxicam Gel Formulations, Acta Pharm, 55, (2), 223-236.

Khaled, M. H, Ahmed, & Seham, S. E. (2013). Preparation and evaluation of orodispersible tablets containing hydroxylbutyl-β-cyclodextrin-simvastatin solid dispersion. Trop. J. Pharm. Res, 12, (4), 469-476.

Leuner, C., & Dressman, J. (2000). Improving drug solubility for oral delivery using solid dispersions. Eur. J. Pharm. Biopharm, 50, (2), 47-60.

Loftsson, T., & Brewster, M. E. (1996). Pharmaceutical applications of β-siklodekstrin, drug solubilization and stabilization. J Pharm Sci, 85, (10), 1017-1024.

Manca, M. L., Zaru, M., Ennas, G., Valenti, D., Sinico, C., Loy, G., & Fadda, A. M. (2005). Diclofenac--Cyclodextrin Binary Systems : Physicochemical Characterization and In Vitro Dissolution and Diffusion Studies, AAPS Pharm. Sci. Tech., 6, (3), 464-472.

Patil, J. S., Kadam D. V., Marapur, S. C., & Kamalapur, M. V. (2010). Inclusion Complex System; A Novel Technique To Improve The Solubility And Bioavailability Of Poorly Soluble Drugs: A Review. International Journal of Pharmaceutical Sciences Review and Research, 2, (2), 29-34.

Prasad, T., Dipti J., & Gaud, R. S. (2011). Formulation and evaluation of extended release solid dispersions containing simvastatin. Asian Journal Of Biomedical And Pharmaceutical Sciences, 1, (3), 13 -19.

Reddy, N., Reddy, A., Srinivasan, S., Kavitha, K., Kumar, R., & Singh, J. (2013). Review On: Better Solubility Enhancement Of Poorly Water Soluble Drugs. Int.J.Inv.Pharm.Sci., 1, (4), 267-273.

Shargel, L., & Yu, A. B. C. (2005). Biofarmasetika dan farmakokinetika terapan. (Edisi Penerjemah: Fasich. Surabaya: Universitas Airlangga Press

DOI: http://dx.doi.org/10.52689/higea.v7i1.114


  • Saat ini tidak ada refbacks.