Pengaruh Ekstrak Etanol Daun Sukun (Artocarpus Altilis (Parkinson Ex F.A. Zorn) Fosberg) terhadap Kadar LDL (Low Density Lipoprotein) pada Mencit Putih Jantan Hiperkolesterol

Helmi Arifin, Zet Rizal, Meri Susilawati

Sari


The research has been about effect of ethanol extract of breadfruit leaves (Artocarpus altillis (Parkinson ex F.A. Zorn) Forsberg) to cholesterol levels in white male mice. Mice used 45 individuals were divided into 5 groups of animal that group I as a negative control group was given only the standard diet food. Group II is the positive control induced hight-fat foods and suspension PTU. Group III, IV and V are given foods containing high fat and suspension PTU with extract variations along with dose of 100, 300, and 900 mg/kg body weight once a day for 7,14 and 21. Then LDL levels measured on day 7, 14, and 21. The results of resarch showed that there are variations influence the dose and duration of administration of the decreased levels of blood LDL white male mice. The highest levels decrease at a dose of 900 mg/kg for 21 day.

Kata Kunci


Artocarpus alltilis; cholesterol; low density lipoprotein

Teks Lengkap:

PDF (English)

Referensi


Fauziah, M. (2005). Tanaman obat keluarga. Jakarta : Penerbit Swadaya.

Hamilton, R.A. (1987). Ten Tropical Fruits of Potential Value for Crop Diversification in Hawaii. Cooperative Extension Services. Hawaii: University of Hawaii at Manoa.

Shimizu, K., Kondo, R., Sakai, K., Buabarn, S. & Dilokkunanant U. 2000. A genanylated chalcone with 5 α-reductase inhibitory properties from Artocarpus Incisus. Phytochemistry 54, 737-739.

Koshihara, Y., Fujimoto, Y. & Inoue, H. (1988). A new 5-lipoxygenase selective inhibitor derived from Artocarpus Communis strongly inhibits arachidonic acid-induced ear edema. Biochemical Pharmacology 37(11), 2161-2165.

Patil, A. D., Freyer, A. L., Killmer, L., Offen, P., Taylor, P. B., Votta, B. J. & Johnson, R. K. (2002). A new dimeric dihydrochalcone and a new prenylated flavone from the bud covers of Artocarpus Altilis: potent inhibitors of cathepsin K. J. Nat. Prod 65, 624-627.

Niu, H., Ma, L., Li, K., Wang, N. & Huang, W. (2015). Genaryl Favonoif From Breadfruit Regulate Dyslipidemia In Hypercholesterolemic Rat. Journal of Food and Nutrition Research 3(6), 399-404.

Anbu, J. (2011). Evaluation Of Antihyperlipidemic Activity Of Ethanolic Extract Of Saussurae Lappa in Rats. International Journal of Pharma and Bio Sciences 2(4), 550-556.




DOI: http://dx.doi.org/10.52689/higea.v7i1.119

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