Pengaruh Ekstrak Etanol Daun Kemangi (Ocimum sanctum L.) Terhadap pH dan Tukak Lambung Pada Tikus Putih Jantan

Sri Oktavia, Helmi Arifin, Ria Irawati

Sari


The effect of basil (Ocimum sanctum L.) leaf ethanolic extract on pH and gastric ulcers in male rats induced by ethanolic absolute 1 mL /200 g BW orally has been evaluated. The observed parameters where pH change gastric liquid and ulcer index value. The result indicated that the basil (Ocimum sanctum L.) leaf ethanolic extract at doses of 100 mg/KgBW. 300 mg/KgBW and 900 mg/KgBW significantly decreased the ulcer index with curative ratio where 45.82 %, 62.94 % and 80.65 % (for one time given extracts for two days), 49.13 %, 77.69 % and 94.62 % (for one time given extract for four days) 52.71 %, 77.67 % and 97.21 % (for one time given extract for six days) compared to the positive control. The extracts at 100 mg/KgBW, 300 mg/KgBW and 900 mg/KgBW also significantly decreased the gastric acid pH to its normal value (P<0.05).

Kata Kunci


Ocimum sanctum; gastric ulcers; pH

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Referensi


Arfin, H. (2013). Daun Dahsyat Pencegah dan Penyembuh Penyakit. Yogyakarta: Penebar Swadya Grup.

Departemen Kesehatan Republik Indonesia. (1995). Materia Medika Indonesia. (Jilid IV). Jakarta: Departemen Kesehatan Republik Indonesia..

Giorgio, P. (2000). Flavonoid an Antioxidant. Journal National Product. 63(1), 1035-1045.

Jones, D.S. (2010). Statistika farmasi. Penerjemah: Hesty Utami Ramadaniati & H. Harrizul Rivai. Jakarta: Penerbit Buku Kedokteran EGC.

Joseph, B., & Nair, V. M. (2013). Ocimum sanctum. (Holy basil): Behind its Anti-Cancerous Effect. Journal of Pharmacognocy and Phytochemistry. 2 (1), 235-240.

Kaur, D., Rana, A. C., Sharma, N., & Kumar, S. (2012). Herbal Drugs With Anti Ulcer Activity. Journal of Applied Pharmaceutical Science. 2 (3), 160-165.

Mahmood, A.A., Al-Bayaty, F. Noor, S.M., Wasman, S.Q., Hussain, S.F. (2011). Antiulcerogenic Effect of Nagilla sativa in Ethanol-Induced Gastric Injuries in Rats. Journal of Medicinal Plans Research. 5(23), 5577-5583.

Mardiana, L. (2012). Daun Ajaib Tumpas Penyakit. Jakarta: Penebar Swadaya Grup.

Pandey, G., & Singht, M. (2010). Pharmacological Activities of Ocimum sanctum. International Journal of Pharmaceutical Sciensces Review and Research. 5 (1), 61-66.

Patil, A. B., & Jadhav, A. S. (2013). Flavonoid and antioxidants: A Review. International Journal of Pharmaceutical and Biological Sciensces Research and Devlopment. 1 (2), 7-20.

Price, S.A., & Wilson, L. (1992). Lambung dan Duodenum. Patofisiologi: Konsep klinis proses-proses penyakit. (4th Ed). Penerjemah: Brahmu Pendit. Jakarta: Penerbit Buku Kedokteran EGC.

Putra, R. (2012). Khasiat Ajaib Kemangi. Yogyakarta: DIVA Press.

Robbins, S.L., & Kumar, V. (2007). Buku Ajar Patologi. (7th Ed). Jakarta: Penerbit Buku Kedokteran EGC.

Sandhar, H. K., Kumar, B., Prasher, S., Tiwari, Salhan, M., & Sharma, P. (2011). A Review of Phytochemistry and Pharmacology of Flavonoid. International Journal Pharmaceutica Science. 1 (1), 25-41.

Syafitri, A. S. (2014). Keamanan dan Khasiat Mutu Kemangi. Yogyakarta: Pustaka Baru Press.

Underwood, J.C.E. (2000). Patologi Umum dan Sistemik. (2th Ed). Penerjemah: Sarjadi. Jakarta: Penerbit Buku Kedokteran EGC.

Vedi, M., Loganathan, B., Chandrasekar, G., Vinagayam, S., Verma, K., Rasool, M., & Sabina, E. P. (2013). Evaluation of Pharmacological Activities of Traditional Herba Drug Ocimum Sanctum in rats. International Journal of Research in Pharmaceutical Sciences. 4 (3), 411-414.

Vogel, H. G. (2002). Drug Discovery and Evaluation: Pharmacological Assays. New York: Springer-Verlage Berlin Heidelberg.

Wattimena, J.R. (1982). L hypoprotinenemie Experimentale Chez La Rat, Explolation pharmacologique Du Modele. (4th Ed). docteur d’ tat Es sciences pharmaceutique, Faculte De Pharmacie universite monpellier I. Dikutip dari Surya Dharma “Pengaruh pemberian indometasin secara intramuscular terhadap lambung tikus putih betina wistar”.Jurnal Sains dan Teknologi Farmasi. 1 (2), 5-11.




DOI: http://dx.doi.org/10.52689/higea.v7i2.125

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