Formulasi Krim Griseofulvin Dan Uji Penetrasi Menggunakan Sel Difusi Franz

Auzal Halim, Iin Indah Sari, Maria Dona Octavia

Sari


Griseofulvin cream formulation and it’s penetration test using Franzs difusion cell has been done. This cream formulation was using two different types of base cream, such as water/oil (w/o) and  oil/water (o/w) base cream type. The vertical type cells of Franz difusion cells, was used for the penetration test and it’s quantity determination was done by using spectrophotometry methods. The result  showed,  that griseofulvin cream with water/oil (w/o) base has the highest of the griseofulvin penetration quantity. The griseofulvin penetration quantity and it’s capacity of penetrating toward water/oil (w/o) and  oil/water (o/w) base are 7,447  µg/mL and 18,54%, then  5,724 µg/mL and 14,39% respectively for 90 minutes periods time. It showed that the cream type can influence the griseofulvin penetration from it’s base. From both cream types, water/oil (w/o) type gives better penetration than oil/water (o/w) cream.


Kata Kunci


Cream Formulation; Griseofulvin; Penetration test; Franz difusion cell

Referensi


Akomeah, F.K., Martin, G.P., Brown, M.B., 2007, Variability in human skin permeability in vitro: Comparing penetrants with different physicochemical properties. J. Pharm. Sci., 96, 824-834.

Ansel, H.C., 1989. Pengantar Bentuk Sediaan Farmasi. Edisi IV, Penerjemah : Farida Ibrahim, Penerbit Universitas Indonesia, Jakarta.

Anief, M., 1994, Farmasetika. Yogyakarta : Gadjah Mada University Press.

Anief, M., 1997, Formulasi Obat Topikal Dengan Dasar Penyakit Kulit. Yogyakarta : Gadjah Mada University Press.

Departemen Kesehatan Republik Indonesia. 1979. Farmakope Indonesia, Edisi III, Jakarta.

Departemen Kesehatan Republik Indonesia, 1985, Formularium Kosmetika Indonesia, Cetakan I, Jakarta.

Djuanda, A., 1999, Ilmu Penyakit Kulit Dan Kelamin, Edisi Ketiga, Fakultas Kedokteran Universitas Indonesia, Jakarta.

Ikatan Sarjana Farmasi Indonesia, 1971, Formularium Medicamentorum Selectum. (Cetakan Keempat). Surabaya : Universitas Airlangga Press.

Lachman, L.H.A, Lieberman, J.L., Kanig, 1989, Teori dan Praktek Farmasi Industri Jilid 1, Edisi III, Penerjemah : Siti Suyatmi, Penerbit Universitas Indonesia, Jakarta.

Lubis, D. H., 2008, Uji penetrasi Krim Griseofulvin Secara Invitro, Skripsi-S1, Fakultas Farmasi, Universitas Andalas, Padang.

Pertiwi, S. A., 2008, Penggunaan Virgin Coconut Oil (VCO) Dalam Formulasi Krim Asam Salisilat Dan Pengaruh Basis Krim Terhadap Liberasinya, Skripsi-S1, Fakultas Farmasi Universitas Andalas, Padang.

Sishu, N.A., 2006, Penetration of Hydrogel of Griseofulvin for Dermal Application. International Journal of Pharmaceutical. Diakses di www.Elseiver.com/locate/jjpharm.

Tjay, T. H., K. Rahardja., 2007, Obat – Obat Penting, Khasiat dan Penggunaanya, Edisi IV, Direktorat Pengawasan Obat dan Makanan Republik Indonesia, Jakarta.

Voight, R., 1994, Buku Pelajaran Teknologi Farmasi, Edisi ke-5, Penerjemah : Drs. Soendani Noerono Soewandhi, Apt., Gadjah Mada University Press, Yogyakarta.




DOI: http://dx.doi.org/10.52689/higea.v4i1.62

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