Pengaruh Pemberian Ekstrak Etanol Herba Ceplukan (Physalis angulata L.) Terhadap Gangguan Fungsi Ginjal Mencit Putih Jantan

Sri Oktavia, Surya Dharma, Anton Yarman

Sari


The research on  this study aims determine the effect of ethanol extract of Ceplukan to renal impairment of white male mice. This plant has many major content of flavonoid and polyphenol which is an antioxidants.. The study is conducted by five treatments i.e. negative control, positive control, dose 375 mg/kgBW, 750 mg/kgBW, and 1,500 mg/kgBW. All groups were induced by gentamicin for 7 days. Serum creatinin level and renal histopathology is determined on days 8 and 16. Serum creatinine level is analyzed by one way ANOVA statistical analysis. It show that there is significant differences between each group (p˂0,05). Renal histopathology analysis shows at doses 1,500 mg/kgBW there are more widespread expansion of the urinary space, repair of glomerulus cells which is  damaged, decrease epithelial cells which is enter into the tubular lumen. It can be concluded that the ethanol extract of ceplukan can repair renal impairment.

Kata Kunci


Physalis angulata L.; Renal; Histopathology

Teks Lengkap:

PDF (English)

Referensi


Dalimartha, S. (2006). Atlas tumbuhan obat. (Edisi 4). Jakarta: Puspa Swara.

Guyton, A.C., Hall, J.E. (1997). Buku ajar fisiologi kedokteran. (Edisi 9). Penerjemah: Setiawan, I. Jakarta: Penerbit EGC.

Hertanto, B. (2012), Efek pemberian subkronis ekstrak etanol biji pala (Myristica fragans. Houtt) pada kadar bun (Blood urea nitrogen) dan kreatinin darah tikus jantan galur witsar. (Skripsi).Yogyakarta: Universitas Ahmad Dahlan.

Junqueira, L.C., J. Carneiro., R.O, Kelley. (1998). Histologi Dasar. Penerjemah:Tambayong, J. Jakarta : Penerbit EGC.

Kardinan, A. (2004), Tumbuhan Suruhan, (Jilid I). Jakarta: PT Agromedia Pustaka.

Liu, D.K, & Chertow, M.G. (2010). Nefrologi dan Gangguan Asam-Basa. EGC: Jakarta.

Nurdawita, (2014). Pengaruh pemberian ekstrak herba ceplukan (Physalis angulata L.) terhadap kadar kalsim dan oksalat sebagai komponen batu ginjal dalam urin tikus putih jantan. (Skripsi). Padang: Sekolah Tinggi Ilmu Farmasi.

Suryani, N., Tinny Endang. H . , Aulanni'am. (2013). Pengaruh ekstrak metanol biji mahoni terhadap peningkatan kadar insulin, penurunan ekspresi TNF-α dan perbaikan jaringan pankreas tikus diabetes. Jurnal Kedokteran Brawijaya. II, (2). 334-338.

Sulistyowati, Y., Pratiwi, R., Setyobroto, I., Anggiana, R. (2013). Pengaruh Pemberian Ekstrak Air Herba Ciplukan (Physalis angulata L.) terhadap Histology Ginjal Tikus Jantan Galur Sparague dawley hiperglikemia. JISBN: VI, (883), 987-979.

Vogel, HG. (2002). Drug Discovery and Evaluations Pharmacological Assays. (2th Edition). Springer-Verlag Berlin Heidelberg. Germany.




DOI: http://dx.doi.org/10.52689/higea.v8i1.136

Refbacks

  • Saat ini tidak ada refbacks.


##submission.license.cc.by-nc-sa4.footer##