Studi Sistem Dispersi Padat Ibuprofen – Manitol Dengan Metode Pelarutan

Rina Wahyuni, Salman Umar, Zulfareda Putri

Sari


Study of solid dispersions of ibuprofen-manitol by solvent method had been researched. Solid dispersions made in 4 ratio formula, F1; F2; F3 and F4 with ibuprofen-manitol ratio  3: 1, 2: 2, 1: 3, and 0.5: 3.5. Evaluation of solid dispersions of Ibuprofen - Manitol include x-ray diffraction (XRD), FT-IR spectroscopy, scanning electron microscopy (SEM), assay and dissolution test. Results of X-ray diffraction solid dispersion system showed a decrease in intensity of the degree of crystalline ibuprofen. SEM characterization results indicated ibuprofen morphological changes towards more amorphous.

Kata Kunci


Ibuprofen; Manitol; Solid Dispersion; Solvent Method

Teks Lengkap:

PDF (English)

Referensi


Almeida, H., Amaral, M. H., & Laboa, P. (2012). Comparatitive Study Of Sustained-Release Lipid Microparticles And Solid Dispersion Containing Ibuprofen. Brazilian Journal Of Pharmaceutical Sciences, 48, (3), 530-536.

Ansel, H. C. (2008). Pengantar Bentuk Sediaan Farmasi (Edisi IV). Penerjemah: F. Ibrahim. Jakarta: Universitas Indonesia.

Hasnain, M. S., Nayak, A, K,. (2012), Solubility And Dissolution Enhanchement Of Ibuprofen By Solid Dispersion Technique Using PEG 6000 - PVP K30 Combination Carrier. Chemistry Bulgarian Journal Science Education, 21, (1), 118-132.

Octavia, M, D., Halim, A., Zaini, E. (2015), Preparation Of Simvastatin-Β-Cyclodextrin Inclusion Using Co-Evaporation Technique, Journal Of Chemical And Pharmaceutical Research, 7, (2), 740-747.

Retnowati, D., Setyawan, D., (2010). Peningkatan Disolusi Ibuprofen Dengan Sistem Dispersi Padat Ibuprofen-PVP K90, Majalah Farmasi Airlangga., 88, (1), 24-28.

Rowe, R. C., Sheskey, P.J & Quinn, M.E. (2012). Handbook of Pharmaceutical Excipients (7th ed). London: Pharmaceutical Press and American Pharmacist Association.

Sameerr, S., Raviraj S, B., & Lalit, Y. (2011), A Review On Solid Dispersion, Int. J. Pharm & Life Sciences. 2, (9), 1078-1095.

Sekharan, T, R., Muthumari, M., Gopal, L., & Esakiyammal, A. (2014), Dissolution Improvement Of Etodolac Using Manitol By Solid Dispersion Method, World Journal Of Pharmacy And Pharmaceutical Sciences. 3, (8), 1206-1216.

Shargel, L & Andrew, B. (1999). Biofarmasetika Dan Farmakokinetika Terapan (Edisi II). Penerjemah: Fasich dan Siti Sjamsiah. Surabaya: Airlangga University Press.

Swarbick, J., & Boylan, J. C. (1991). Encyclopedia of Pharmaceutical Technology (Volume 5). New York and Bassel: Marcell Dekker Inc.

The Department Of Health. (2009). British Pharmacopoeiea. London: The Stationery Office.

Voight, R. (1994). Buku Pelajaran Teknologi Farmasi, (Edisi V), Penerjemah Soewandi Noerono, Yogyakarta: Gajah Mada University Press.

Watson, D. G. (2009). Analisis Farmasi Buku Ajar. (Edisi 2). Penerjemah: Winny R. Syarief. Jakarta: Penerbit Buku Kedokteran ECG

Whalley, W. B., & Langway, C. C. (1979). A Scanning Electron Microscopy Examination Of Subglacial Quartz Grains From Camp Century Core. Journal of Galciology. 25,(91), 171-207.

Xu, L., Li, S. M., & Sunada, H. (2007). Preparation And Evaluation Of Ibuprofen Solid Dispersion Systems With Kollidon Particles Using A Pulse Combustion Dryer System. Chem Pharm Bull, 55, (11), 1545-1550.




DOI: http://dx.doi.org/10.52689/higea.v8i1.140

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