Uji Aktivitas Ekstrak Herba Sambiloto (Andrographis paniculata (Burm.f.) Ness) Terhadap Kadar Nitrogen Monoksida Pada Mencit Putih Jantan Hiperkolesterolemia

Aried Eriadi; Suhatri Suhatri; Nindywaii Honolhulu

doi:10.52689/higea.v9i1.152

Uji Aktivitas Ekstrak Herba Sambiloto (Andrographis paniculata (Burm.f.) Ness) Terhadap Kadar Nitrogen Monoksida Pada Mencit Putih Jantan Hiperkolesterolemia

Aried Eriadi, Suhatri Suhatri, Nindywaii Honolhulu

Sari

Effect of extract of bitter herbs (Andrographis paniculata (Burm.f.) Ness) has conducted research on the levels of NO in hypercholesterolemic male white mice. Hypercholesterolemia was induced by high-fat foods and propylthiouracil. Bitter herbs extract was administered orally every day for 60 days with a dose of 25 mg/kg BB, 50 mg/kg BB, and 100 mg/kg BB. The negative control group was only given regular meals and a positive control group was given a high-fat foods and propylthiouracil. Parameters measured were the levels of NO in serum. The results showed that the extract of bitter herbs can increase blood levels of NO white male mice when compared to the positive control (hypercholesterolemia), but still lower than the negative control (normal animals) (P<0.05). While the old factor does not affect the administration of organ weight ratio of the heart, liver and kidneys and significantly (P>0.05).

Kata Kunci

Sambiloto; Nitric Oxide; Hypercholesterolemia

Teks Lengkap:

PDF (English)

Referensi

Corwin, E. J. (2000). Buku saku patofisiologi. Penerjemah: B. U. Pendit. Jakarta: Penerbit Buku Kedokteran Kedokteran EGC.

Dalimartha, S. (2000). Atlas tumbuhan obat Indonesia. (Jilid 2). Jakarta: Trubus Agriwidya.

Jarukamjorn, K. & Nobuo, N. (2008). Pharmacological aspects of Andrographis paniculata on health and its major diterpenoid constituen andrographolide. Journal of Health Science, 54, (4), 370-381.

Jones, D. S. (2010). Statistik farmasi. Penerjemah: H. Rivai. Jakarta: Penerbit EGC.

Kumar, V., Cotran, R. S., & Robbins, S. L. (2007). Buku ajar patologi 2. Penerjemah: I. W. Septelia. Jakarta: Penerbit Buku Kedokteran EGC.

Marx, J. L. (1985). Oxygen free radicals linked to many diseases. Science, 235, 529-531.

Mishra, K. S., Dash, A. P., & Dey, N. (2007). Andrographis paniculata (Kalmegh): A. Review. Pharmacognosy Review, 1, (2), 283-298.

Radha, R., Sermakkani, M., & Thangapandian, V. (2011). Evaluation of phytochemical and antimicrobial activity of Andrographis paniculata nees (Acanthaceae) aerial parts. International Journal Of Pharmacy & Life Sciences, 2, (2), 562- 567.

Rahmat, A., Baharudin, B. R., & Bakar, M. F. A. (2006). Effects of andrographis paniculata crude extract in normal and alloxan induced hyperglycaemic rats. Journal of Biological Sciences, 6, (1), 92-95.

Sudoyo, A. W. (2009). Buku ajar ilmu penyakit dalam jilid III. (Edisi 5). Jakarta: Internal Publishing.

Vijaykumar, K., Murthy, P. B. S., Kannababu, S., Syamasundar, B., & Subbaraju, G. V. (2007). Estimation of andrographolide in andrographis paniculata herb, extract and dosage forms. International Journal of Applied Science and Engineering, 5, (1), 27-39.

Vogel. G. (2002). Drug discovery and evaluation pharmacological assays. German: Springer-Verlag Berlin Heidelberg.

Widyawati, T. (2007). Aspek farmakologi sambiloto (Andrographis paniculata Ness.). Majalah Kedokteran Nusantara, 40, (3), 216-220.

Winarsi, H. (2007). Antioksidan alami dan radikal bebas. Yogyakarta: Kanisius

DOI: http://dx.doi.org/10.52689/higea.v9i1.152