Pengaruh Hasil Fraksinasi Ekstrak Daun Kemangi (Ocimum sanctum L.) Terhadap Aktivitas Susunan Saraf Pusat Pada Mencit Putih Jantan

Rahimatul Uthia, Helmi Arifin, Feni Efrianti

Sari


Study about activity of the central nervous system stimulant of  breadfruit’s leaf the water fraction Ocimum santum L. Using experimental animals  male white mice (Mus musculus, L) has been done. Breadfruit’s leaf the water fraction at a dose of 25 mg/kg BW, 50 mg/kg BW and 100 mg/kg BW given to mice orally 15 days. Stimulant activity was tested on day -5, -10 and -15. As a comparison used caffeine 13 mg/kg BW while luminal 50 mg/kg BW is used to test a long sleep induction and sleep in mice. Parameters used stimulant activity is endurance test with Rotary road equipment, test sensor activity and test motor activity wiht a Automotic hole board and sleep induction test and a long sleep. From the research that has been done, it is know that kemangi leaf the water fraction at a 25 mg/kg BW, 50 mg/kg BW and 100 mg/kg BW have a central nervous system stimulan activity by increasing endurance, sensor activity and motor activity as well as increase the time to accelerate the induction of sleep and long sleep in mice sigficantly (P>0,05).

Kata Kunci


Water Fraction; Stimulant; Caffeine

Teks Lengkap:

PDF (English)

Referensi


Departemen Kesehatan Republik Indonesia. (2000). Parameter standar umum ekstrak tumbuhan obat. Jakarta: Direktorat Jendral Pengawasan Obat dan Makanan. Direktorat Pengawasan Obat dan Makanan.

Gan, S., Setiabudy, R., Sjamsudin, U., & Bustami ZS. (1987). Farmakologi dan terapi (Edisi 3). Jakarta: Bagian Farmakologi Fakultas Kedokteran Universitas Indonesia.

Goodman, L. S., & Gilman’s, A. G. (1990). The pharmacological basic of therapeutic (Eight Edition). New York: Pergamon Press.

Goodman, L. S., & Gilman’s, A. G. (2006). Dasar farmakologi dan terapi. (Edisi 10). Diterjemahkan oleh tim alih bahasa sekolah. Bandung: Penerbit ITB.

Graham, J. D. P. (1971). Pharmacology for medical student (2nd edition). London: Toront University.

Handa, S. S., Khanuja, S. P. S., Longo, G & Rakesh, D., D. (2008). Extraction Thechnologies for medicinal and aromatic plants. Int. Center for Science And High Technology Italy. Italy: ICSUMDO.

Harborne JB., (1987). Metoda Fitokimia, Penentuan Cara Modern Menganalisa Tumbuhan. Terjemahan K. Padmawinata. (Edisi II). Bandung: Penerbit ITB.

Jeremy, P. E. S., David. V., & Catarina. R., (2009). Flavonoids and cognition: The molecular mechanisms underlying their behavioural effects. Archives of Biochemistry and Biophysics. 492(1–2). 1-9.

Jumianurti, N., (2015). Efek Antiinflamasi Ekstrak Etanol Daun Kemangi (Ocimum Sanctum L.) Secara Topikal Dan Penentuan Jumlah Sel Leukosit Pada Mencit Putih Jantan (Skripsi). Padang : Sekolah Tinggi Ilmu Farmasi Padang.

Katzung, B. G. (2002). Farmakologi dasar dan klinis. (Edisi 8). Penerjemah Dripa Sjaban, Jakarta: Salemba Medika.

Katzung, B. G. (2007). Farmakologi dasar dan klinik (Basic and clinical pharmacology). Edisi 10. Jakarta: Penerbit buku kedokteran EGC.

Niture, SK., Rao, US., & Srivenugopal K,. (2006), Chemopreventative strategies targeting the MGMT repair protein: Augmented expression in human lymphocytes and kanker cell by ethanolit and aqueous extracts of several Indian medicinal plants. Internasional Journal Of Oncology 29:1269-1278.

Raymond, C. R & Paul, S., (2003). Handbook of Pharmaceutical Excipients, Fourth Edition, New York: Pharmaceutical Press.

Vogel, H., G. (2002). Drug discovery and evaluation pharmacological assay. Springer Varleg. Berlind. Heidenlherg. 764-765.

Widjaja, E., A., Rahayuningsih, Y., Rahajoe, J., S., Ubaidillah, R., Maryanto, I., Walujo, E., B & Semiadi, G. (2014). Kekinian Keanekaragaman Hayati Indonesia. (Edisi I). Jakarta: LIPI Press.




DOI: http://dx.doi.org/10.52689/higea.v9i1.161

Refbacks

  • Saat ini tidak ada refbacks.


##submission.license.cc.by-nc-sa4.footer##

Slot gacor maxwin