Pengaruh Polivinilpirolidon K-30 terhadap Disolusi Ketoprofen dalam Sistem Dispersi Padat

Rieke Azhar; Muslim Suardi; Salman Umar

doi:10.52689/higea.v1i1.2

Pengaruh Polivinilpirolidon K-30 terhadap Disolusi Ketoprofen dalam Sistem Dispersi Padat

Rieke Azhar, Muslim Suardi, Salman Umar

Sari

Effects of polyvinylpyrrolidone K-30 on dissolution characteristics of solid dispersionÂ systems have been studied. Solid dispersions were prepared by solvent method using several ratiosÂ of ketoprofen-polyvinylpyrrolidone K-30 as follows 1:9, 3:7, 5:5, 7:3, 9:1. Physical mixtures ofÂ ketoprofen-polyvinylpyrrolidone K-30 were used as a comparison. The solid dispersion systemsÂ and physical mixtures were evaluated for physicochemical properties and dissolutionÂ characteristics. Dissolution tests were measure with modified basket method using pH 7.2Â phosphate buffer as dissolution medium. Samples were taken up after 5, 10, 15, 20, 30, 45, and 60Â minutes. Results generally showed that solid dispersion system of ketoprofenpolyvinylpyrrolidoneÂ K-30 have a different physicochemical properties compared to physicalÂ mixtures and pure ketoprofen and exhibited better dissolution rate and dissolution efficiency ofÂ ketoprofen. Dissolution efficiency and dissolution rate constant of the solid dispersion system wereÂ 59.41%, and 1.66 mg/s, respectively.

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DOI: http://dx.doi.org/10.52689/higea.v1i1.2

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