Uji Disolusi Beberapa Tablet Parasetamol yang Ada di Perdagangan
Sari
The dissolution test four generic tablets and one branded name of parasetamol tablets has been undertaken. Method applied was in the paddle method as required by Pharmacopea of Indonesian ed. IV. Paracetamol concentration measured spectrophotometrically at maximum wave length of 243 nm in dissolution medium pH 5.8 phosphate buffer solution. The result dissolution test to comply with tolerance is not less than 80% of the labeled amount of paracetamol is dissolved in tweenty minutes. The dissolution about drown from the plot between percentage of paracetamol dissolved versus time.The percentage of paracetamol dissolved at T30 analyzed by using ANOVA test. Result showed in the dissolution rates between generic 1,2,3,4 and branded name were significant different take. Then continued to DUNNET test , only generic 2 tablets was not significantly difference whereas the other generic tablets were significant differences.
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PDF (English)Referensi
Departemen Kesehatan Republik Indonesia, “Farmakope Indonesia”, Edisi IV,
Jakarta, 1995
Dollery, Sir Collin., “Therapeutic Drugs”, Volume 2, Churchill Living Stone, Edinburg London, Melbourne, New York, Tokyo and Madrid, 1997
Goodman & Gilman’s., “The Pharmacological Basis of Therapeutics”, 10Th ed,, 2003
“Farmakologi dan Terapi”, edisi 4, cetak ulang bagian Farmakologi, Fakultas
Kedokteran UI, 1995
Halim, A., Penelitian Terhadap Daya Penyerapan Air, beberapa Tepung yang Digunakan dalam Bidang Farmasi, “Jurnal Penelitian dan Pengabdian Masyarakat” No. 6 / Januari / Tahun 1991, hal 83
Halim, A., “Teknologi Partikel”, FMIPA, Universitas Andalas, Padang, 1991 Lachman, L.H.A. Lieberman, dan J.L. Kanig., Teori dan Praktek Farmasi Industri II”, Ed. IIII diterjemahkan oleh Siti Suyatmi, Penerbit Universitas Indonesia, Jakarta, 1994
Katzung, G, Bertman,, “Basic and Clinical Pharmacology”, eight edition, Departement of Cellular and Molecular Pharmacology University of California,
San Fransisco, 2002
Tjay,T.H., dan R, Kirana, “Obat-obat Penting”, Edisi V, Jakarta, 2002
Voigt, R., “Buku Pelajaran Teknologi Farmasi”, edisi V, diterjemahkan oleh Soendani Noerono, Gajah Mada University Press, Yogyakarta, 1994
DOI: http://dx.doi.org/10.52689/higea.v1i1.4
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