Penggunaan Biopolimer Polikaprolakton Sebagai Matrik Herbisida Lepas Lambat Asam 2,4-Diklorofenoksi Asetat

Akmal Djamaan; Maria Ulfa; Netty Suharti

doi:10.52689/higea.v4i2.69

Penggunaan Biopolimer Polikaprolakton Sebagai Matrik Herbisida Lepas Lambat Asam 2,4-Diklorofenoksi Asetat

Akmal Djamaan, Maria Ulfa, Netty Suharti

Sari

The formulation of microcapsule of 2,4-dichlorophenoxy acetate acid using biopolymer polycaprolactone as a matrix using solvent evaporation method has been carried out. The microcapsule formula was used three types with the ratio 2:1, 1:1, 1:2 between 2,4-dichlorophenoxy acetate acid and polycaprolactone. Distribution particle test was used calibrated microscope. Active substance release test was detected by UV-Vis spectrophotometer. Polycaprolactone can be used as the matrix polymer for slow release preparations and influence to the release of active substance 2,4-dichlorophenoxyacetate acid. Result showed that recovery test of the formula-2 containing 86.5 % higher than formula-1, 84.5% and formula-3 78.2%. Model of the kinetics of the release active substance from microcapsule which correlation coefficient close to one is formula-1 which follow zero order kinetics.

Kata Kunci

polikaporolakton, 2,4-D, herbisida

Teks Lengkap:

PDF (English)

Referensi

Banakar, U.V., 1991,Pharmaceutical Dissolution Testing, Marcel Dekker Inc, New York.

Benita, S., 2006, Microencapsulation Methods and Industrial Application (Edisi 2), New York: Marcel Dekker Inc.

Day, R.A., Underwood, A.L., Hillarius, W.H., Simarmata, L., 2002, Analisis Kimia Kuantitatif(Edisi 6), Alih bahasa oleh Sopyan, Erlangga, Jakarta.

Elzubair, A., Elias, C. N., Suarez J. C. M., Lopes, H.P., Vieira, M.V.B., 2006, The Physical Characterization of a Ther Moplastic Polymer for Endodontic Obturation. Journal of Dentistry, 34, 784-789.

Edwards,D., 2005, Reregistration Eligibility Decision for 2,4-D List aCase 0073, United States Environmental Protection Agency.

Garabrant, D.H., Philbert, M.A., 2002, Review of 2,4-Dichlorophenoxyacetic Acid (2,4-D) Epidemiology and Toxicology, Critical Reviews in Toxicology, 32 (4), 233-257.

Goeswin,A., 2010, Enkapsulasi Farmasetik.Bandung: penerbit ITB.

Lachman, L., Lieberman, H., Kanig, J.L., 2008,Teori dan praktek Farmasi Industri II (Edisi 3),Terjemahan Siti Suyatmi,Jakarta: UI Press.

Martin, A., Swarbrick, J., Cammarata, A., 1993,Farmasi Fisik, Dasar-Dasar Kimia Fisik Dalam Ilmu Farmasetik (Edisi 3). Terjemahan Yoshita,Jakarta: UI Press.

Oktavia, S., 2011, Penggunaan Poli (3-Hidroksi Butirat Sebagai Penyalut dalam Formulasi Mikrokapsul Etinil Estradiol, Skripsi, Padang: Universitas Andalas.

Sudarmo, S., 1991, Pestisida Yogyakarta : Penerbit Kanisius.

Triharso, 2004, Dasar-dasar Perlindungan Tanaman, Yogyakarta: Gadjah Mada University Press.

DOI: http://dx.doi.org/10.52689/higea.v4i2.69