Mikroenkapsulasi Metronidazol Dengan Polimer Hpmc Menggunakan Metoda Penguapan Pelarut

Auzal Halim; Reni Daniati; Rina Wahyuni

doi:10.52689/higea.v5i1.78

Mikroenkapsulasi Metronidazol Dengan Polimer Hpmc Menggunakan Metoda Penguapan Pelarut

Auzal Halim, Reni Daniati, Rina Wahyuni

Sari

Microencapsulation of metronidazole using HPMC as a polymer by solvent evaporation method had been studied. Microcapsulhad been made into3formulation with 3 ratio variation between Metronidazole and HPMC, 1:1; 1:1.5; 1:2. Microcapsules were analyzed by SEM, DTA, FT-IR, particle sized distribution and dissolution profile. Microcapsules were white to slightly yellow and almost perfectly spherical.Disolution profiles of microcapsules showed that the greater amount of HPMC gave the slower release ofMetronidazole. Dissolution kinetics of microcapsule allowedHiguchi equation, where the realese of MetronidazoleÂ from microcapsules were controlled by diffution process.

Kata Kunci

Microencapsulation, Metronidazole and HPMC

Teks Lengkap:

PDF (English)

Referensi

Abdou, H.M., 1989, Dissolution, Bioavaibility and Bioequivalence, Pennsylavania: Mark Publishing Company Easton.

Ansel, H. C., 1989, Pengantar Bentuk Sediaan Farmasi (Edisi 4), Terjemahan: Farida Ibrahim, Jakarta: Universitas Indonesia Press.

Departemen Kesehatan Republik Indonesia, 1995, Farmakope Indonesia (Edisi 4). Jakarta.

Ganiswara, G & Sulistia, 1995, Farmakologi dan Terapi (Edisi 4) Bagian Farmakologi, Fakultas Kedokteran Universitas Indonesia, Jakarta.

Gennaro, A.R., 1985, Remington Pharmaceutical Sciences (17th ed), Easton: Mack Publishing Company.

Lachman, L., Lieberman, H.A & Kaning, J.L., 1994, Teori dan Praktek Farmasi Industri (Edisi 2), Terjemahan: Siti Suyatmi, Jakarta: Universitas Indonesia Press..

Shargel, L., & Yu, A.B.C., 2005, Biofarmasetika dan Farmakokinetika Terapan (Edisi 2). Terjemahan: Fasich. Surabaya: Universitas Airlangga Press.

Sutriyo., Djajadisastra, J., & Novitasari, A., 2004, Mikroenkapsulasi Propanolol Hidroklorida dengan Penyalut Etil Selulosa Menggunakan Metoda Penguapan Pelarut, Majalah Ilmu Kefarmasian, 1(2): 93-101.

The United States Pharmacopoeial Convention., 2007, The United States of pharmacopoeia (ã€–30ã€—^th ed.), New York: United StatePharmacopeial Convertion Inc.

Tjay, H. T. & Rahardja, K., 2007, Obat-Obat Penting (Edisi 6), Jakarta: PT. Elex Media Komputindo Gramedia.

Wade, A., & Weller, P. J., 1994, Handbook of Pharmaceutical Excipient (2nd ed), The Pharmaceutical Press London.

Watson, D. G., 2009, Analisis Farmasi (Edisi 2), Terjemahan: Winny R. Syarief, Jakarta: Penerbit Buku Kedokteran EGC.

DOI: http://dx.doi.org/10.52689/higea.v5i1.78

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