Pengaruh Ekstrak Etanol Daun Sirsak (Annona Muricata L.) Terhadap Kadar LDL Pada Mencit Putih Jantan

Surya Dharma, Oki Supanda, Elisma Elisma

Sari


Study about the influence of the aethanolic extract of Annona muricata L on male mice induced by high fat diet and propylthiouracil has been done. The aethanolic extract of Annona muricata L was given orally one a day for 7, 14, and 21 days. The doses used were 2, 6, 18 mg/20 g body weight respectively. Negative control group was given standard food. Parameters were measured blood levels of LDL. Result showed that the giving of the aethonalic extract of Annona muricata could decrease blood levels of LDL significantly (p> 0.05). Whereas the factors of the days does not show significantly (p> 0.05).

Kata Kunci


The Aethanolic Extract of Annona muricata L; LDL; Fotometer Clinical.

Teks Lengkap:

PDF (English)

Referensi


Adeyemi, D.O., Komolafe, O.A., Adewole, S.O., Obuator, E.M. (2009). Antihyperlipidemic activities of Annona muricata Linn. Int. J. Alt. Med. Volume 7 (1);1-8.

Champy, P., Melot, A., Guerineau, E. V., Gleye, C., Fall, D., Hoglinger, G.U., Ruberg, M., Lannuzel, A., Laprovote, O., Laurens, A., Hocquemiller, R. (2005). Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in guadeloupe. Mov. Disord. 20, (12), 1629-1633

Departemen Kesehatan RI, Direktorat Jendral Pengawasan Obat dan Makanan, Direktorat Pengawasan Obat Tradisional. (2000). Parameter standar umum ekstrak tumbuhan obat.(Cetakan I). Jakarta: Depatemen Kesehatan

Departemen Kesehatan RI. (1979). Farmakope Indonesia. (Edisi 3). Jakarta : Departemen Kesehatan Republik Indonesia.

Departemen Kesehatan RI. (2008). Farmakope Herbal Indonesia. (Edisi 1). Jakarta : Departemen Kesehatan Republik Indonesia.

Foong, P.C., Hamid, R.A. (2012). Evaluation of anti-inflamatory activities of ethanolic extract of Annona muricata leaves. Def. Bio. Sci. Vol 22, (6): 1301-1307.

Gajalakshmi, S., Vijayalakshmi, V., Devi, R. (2011). Phytochemical and pharmacological properties of Annona muricata. International Journal of Pharmacy and Pharmaceutical Sciences. Vol 4, 3-6.

Ganiswara, G. S. (1995).Farmakologi dan terapi. (Edisi IV). Jakarta: Bagian Farmakologi, Fakultas Kedokteran, Universitas Indonesia.

George, V.C., Kumar, DR. N., Rajkumar, V., Suresh, PK., Kumar R.A. (2012). Quantitative assessment of the relative antineoplastic potensial of the n-butanolic Leaf extract of Annona muricata Linn. in normal and immortalized human cell lines. Asian. Pac. J. Cancer. Prev. Vol 13, 699-704.

Hasnawati, E. (2012). Keajaiban sirsak menumpas 7 penyakit yang mematikan. Yogyakarta: Easy Media.

Hasrat, JA., De, Bruyne, T., De, Backer, JP., Vauquelin, G., Vlietinck, AJ. (1997). Isoquinoline Derivatives Isolated from the Fruit of Annona muricata as 5-HTergic 5-HT1A Receptor Agonists in Rats: Unexploited Antidepressive (Lead) Products. J. Pharm. Pharmacol. Vol 49, 1145-1149.

Jones, D. S. (2010). Statistika farmasi. Penerjemah Harrizul Rivai dan Hesty Utami Ramadaniati. Jakarta: Penerbit EGC.

Jones, P.J., Sarjaz, M.R., Ntanios, F.Y., Vanstone, C.A., Feng, J.Y., Parsons, W.E., (2000). Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus pytostanol esters. J. Lipid Research. Vol 41, 697-705.

Kim, G.S., Zeng, L., Alali, F., Rogers, L.L., Wu, F.E., Sastrodihardjo, S., Mclaughlin, J.L. (1998). Muricoreacin and murihexocin C mono-tetrahydroufuran acetogenins from the leaves of Annona muricata. Phytochemistry. 38(1) : 454-460.

Melo, J.G And Thiago, A.S.A.(2010), Antiproliterative Activity, Antioxidant Capacity and Tannin content in plants of semi- Arid Northeastein Brazil. J. Molecules, 15, 8534-8542.

Murray, R. K., Granner D. K., Mayes, P. A. & Rodwell V. W. (2006). Biokimia Harper. (Edisi ke-25).Diterjemahkan oleh A. Hartono. Jakarta: Penerbit Buku Kedokteran EGC.

Nwokocha, CR., Owu, DU., Gordon, A., Thaxter, K., Mccalla, G., Ozolua, RI., Young, L. (2012). Possible mechanism of action of the hypotensive effect of Annona muricata (soursop) in normotensive Sprague-Dawley rats. Phar. Biol. Vol 50, 1436-1441.

Osorio, E., Arango, GJ., Jimenez, N., Alzate F., Ruiz G., Gutierrez, D., Paco, MA., Gimenez, A., Robledo, S. (2007). Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae. J. Ethnopharmacol. Vol 111, (3), 630-635.

Padma, P., Pramod N.P., Thyagarajan S.P., dan Khosa R.L. (1999). Effect of the extract of Annona muricata and Petunia nyctaginiflora on herpes simplex virus. Journal Ethnopharmacol. 61(1):81-83.

Pathak, P., Saraswathy., Vora, A., Saval J. (2010). In vitro antimicrobial activity and phytochemical analysis of the leaves of Annona muricata. Inter Journal of Pharma Research and Development. 2(5),1-6.

Price, S. A., & Wilson, N. L. (2006). Patofisiologi konsep klinis proses-proses penyakit.(Edisi 6). Penerjemah H. Hartanto dkk. Jakarta : Penerbit Buku Kedokteran EGC.

Prusti, A., Mishra, S. R., Sahoo, S. & Mishra, S. K. (2008). Antibacterial activity of some Indian medicinal plants. Journal of Ethnobotanial Leaflets. 12, 227-230.

Somasundaram, J. (2013). Evaluation of laxative effect of ethanol extract of leaves of Annona muricata L. Int. J. Innovative Drug Discovery. Vol 3(1): 28-32.




DOI: http://dx.doi.org/10.52689/higea.v6i1.98

Refbacks

  • Saat ini tidak ada refbacks.


##submission.license.cc.by-nc-sa4.footer##

Slot gacor maxwin