Pengaruh Penggunaan Aerosil Terhadap Disolusi Tablet Isoniazid (Inh) Cetak Langsung

Syofyan Syofyan, Thika Dwi Lestari, Rieke Azhar

Sari


The research about the effect of aerosil to the dissolution rate of isoniazid tablet with direct compression method has been done. Isoniazid tablets were made with different aerosil consentration in each formulas, that is 0.5%; 1%; 1.5%. Tablet evaluation were done by measuring drug loading assay and dissolution test using HCl 0.1 N. The assay was measured using spectrophotometer UV at 266.5nm; where obtained levels of isoniazid tablets in each formulas is 95.779% - 103.776%. The results of disolution test showed that every formulas reached the 80% of cumulatif persentage as follows, 98.671%; 98.441%; 98.327% at 45th minutes. The result concluded that the addition of execessive aerosil as lubricant can decreased tablet disintegration rate and dissolution rate.

Kata Kunci


Isoniazid; Aerosil; Tablet; Direct Compression

Teks Lengkap:

PDF (English)

Referensi


Ben, E.S. (2008). Teknologi tablet. Padang: Penerbit Universitas Andalas.

Departemen Kesehatan Republik Indonesia. (1979). Farmakope Indonesia (Edisi III), Jakarta

Departemen Kesehatan Republik Indonesia. (1995). Farmakope Indonesia (Edisi IV), Jakarta

Gohel, M.C. & Jogani, P. D. (2005). A review of coprocess directly compressible excipients. J. Pharm Sci, 8, (1).

Halim, A. (2012). Farmasi fisika pulva engginering. Padang: Penerbit Universitas Andalas.

Lachman, L., H. A. Lieberman & Kanig, J. L. (1994). Teori dan praktek farmasi industri I (edisi II). Penerjemah: S. Suryatmi. Jakarta: Penerbit Universitas Indonesia.

Rowe, C. R, Paul J shaskey and Owen C. (2006). Handbook of Pharmaceutical Exipients (edisi 5). The Pharmaceutical press and American Pharmacists Associaton.

Siregar, C. J. P. Charles. (2010). Sediaan tablet dasar – dasar praktis, Jakarta: Buku Kedokteran EGC.

Syamsuni, H. (2006). Farmasetika dasar dan hitungan farmasi. Jakarta: Penerbit buku kedokteran.

The United States of Pharmacopeia. (1995). (30th ed). New York : United State Pharmacopeial Convertion Inc.

Voight, R. (1994). Buku Pelajaran teknologi farmasi (edisi 5). Penerjemah: S. Noerono. Yogyakarta: Penerbit Gajah Mada University.




DOI: http://dx.doi.org/10.52689/higea.v6i1.99

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