ojs2 has produced an error Message: CAUGHT EXCEPTION: ini_set(): Cannot set 'user' save handler by ini_set() or session_module_name() In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/session/SessionManager.inc.php At line: 37 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of GenericPlugin::manage($verb, $args, &$message, &$messageParams) should be compatible with PKPPlugin::manage($verb, $args, &$message, &$messageParams, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/plugins/GenericPlugin.inc.php At line: 58 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of WebFeedPlugin::getManagementVerbs() should be compatible with GenericPlugin::getManagementVerbs($verbs = Array) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/webFeed/WebFeedPlugin.inc.php At line: 147 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of TinyMCEPlugin::getManagementVerbs() should be compatible with GenericPlugin::getManagementVerbs($verbs = Array) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/tinymce/TinyMCEPlugin.inc.php At line: 425 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of CustomBlockManagerPlugin::getManagementVerbs() should be compatible with GenericPlugin::getManagementVerbs($verbs = Array) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/customBlockManager/CustomBlockManagerPlugin.inc.php At line: 72 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of StaticPagesPlugin::getManagementVerbs() should be compatible with GenericPlugin::getManagementVerbs($verbs = Array) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/staticPages/StaticPagesPlugin.inc.php At line: 83 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of AcronPlugin::getManagementVerbs() should be compatible with GenericPlugin::getManagementVerbs($verbs = Array) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/acron/AcronPlugin.inc.php At line: 87 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of AcronPlugin::manage($verb, $args, &$message) should be compatible with GenericPlugin::manage($verb, $args, &$message, &$messageParams) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/acron/AcronPlugin.inc.php At line: 104 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of UsageEventPlugin::getManagementVerbs() should be compatible with GenericPlugin::getManagementVerbs($verbs = Array) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/usageEvent/UsageEventPlugin.inc.php At line: 79 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of ReferralPlugin::getManagementVerbs() should be compatible with GenericPlugin::getManagementVerbs($verbs = Array) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/referral/ReferralPlugin.inc.php At line: 44 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of UsageStatsPlugin::getManagementVerbs() should be compatible with GenericPlugin::getManagementVerbs($verbs = Array) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/usageStats/UsageStatsPlugin.inc.php At line: 186 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of ReportPlugin::manage($verb, $args) should be compatible with PKPPlugin::manage($verb, $args, &$message, &$messageParams, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/classes/plugins/ReportPlugin.inc.php At line: 231 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of ArticleHandler::validate(&$request, $articleId, $galleyId = NULL) should be compatible with PKPHandler::validate($requiredContexts = NULL, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/pages/article/ArticleHandler.inc.php At line: 412 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of ArticleHandler::setupTemplate($request) should be compatible with PKPHandler::setupTemplate() In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/pages/article/ArticleHandler.inc.php At line: 542 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
NOTICE: Only variables should be passed by reference (/home/jurn44120/public_html/jurnalfarmasihigea.org/pages/article/ArticleHandler.inc.php:41)
NOTICE: Only variables should be passed by reference (/home/jurn44120/public_html/jurnalfarmasihigea.org/pages/article/ArticleHandler.inc.php:42)
NOTICE: Only variables should be passed by reference (/home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/handler/PKPHandler.inc.php:254)
NOTICE: Only variables should be passed by reference (/home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/handler/PKPHandler.inc.php:259)
ojs2 has produced an error Message: WARNING: Parameter 2 to ArticleHandler::view() expected to be a reference, value given In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/core/PKPRouter.inc.php At line: 362 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of InstitutionalSubscription::isValid($domain, $IP, $check = SUBSCRIPTION_DATE_BOTH, $checkDate = NULL) should be compatible with Subscription::isValid($check = SUBSCRIPTION_DATE_BOTH, $checkDate = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/classes/subscription/InstitutionalSubscription.inc.php At line: 121 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of CitationDAO::getInsertId() should be compatible with DAO::getInsertId($table = '', $id = '', $callHooks = true) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/citation/CitationDAO.inc.php At line: 463 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of PubIdPlugin::manage($verb, $args) should be compatible with PKPPlugin::manage($verb, $args, &$message, &$messageParams, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/classes/plugins/PubIdPlugin.inc.php At line: 77 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of DOIPubIdPlugin::getPubId(&$pubObject, $preview = false) should be compatible with PubIdPlugin::getPubId($pubObject, $preview = false) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/pubIds/doi/DOIPubIdPlugin.inc.php At line: 68 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Cannot modify header information - headers already sent by (output started at /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/core/PKPApplication.inc.php:381) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/template/PKPTemplateManager.inc.php At line: 340 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Cannot modify header information - headers already sent by (output started at /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/core/PKPApplication.inc.php:381) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/template/PKPTemplateManager.inc.php At line: 343 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of InformationBlockPlugin::getContents(&$templateMgr) should be compatible with BlockPlugin::getContents(&$templateMgr, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/blocks/information/InformationBlockPlugin.inc.php At line: 47 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of AuthorBiosBlockPlugin::getContents(&$templateMgr) should be compatible with BlockPlugin::getContents(&$templateMgr, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/blocks/authorBios/AuthorBiosBlockPlugin.inc.php At line: 47 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of NotificationBlockPlugin::getContents(&$templateMgr) should be compatible with BlockPlugin::getContents(&$templateMgr, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/blocks/notification/NotificationBlockPlugin.inc.php At line: 60 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of SubscriptionBlockPlugin::getContents(&$templateMgr, $request) should be compatible with BlockPlugin::getContents(&$templateMgr, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/blocks/subscription/SubscriptionBlockPlugin.inc.php At line: 49 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of LanguageToggleBlockPlugin::getContents(&$templateMgr) should be compatible with BlockPlugin::getContents(&$templateMgr, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/blocks/languageToggle/LanguageToggleBlockPlugin.inc.php At line: 81 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
ojs2 has produced an error Message: WARNING: Declaration of WebFeedBlockPlugin::getContents(&$templateMgr) should be compatible with BlockPlugin::getContents(&$templateMgr, $request = NULL) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/plugins/generic/webFeed/WebFeedBlockPlugin.inc.php At line: 98 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve
UJI AKTIVITAS SITOTOKSIK EKSTRAK n-HEKSAN DAUN ALPUKAT (Persea americana Mill) TERHADAP SEL KANKER KULIT B16F0 DENGAN METODE MICROCULTURE TETRAZOLIUM TEST | Aulia Bakhtra | Jurnal Farmasi Higea

UJI AKTIVITAS SITOTOKSIK EKSTRAK n-HEKSAN DAUN ALPUKAT (Persea americana Mill) TERHADAP SEL KANKER KULIT B16F0 DENGAN METODE MICROCULTURE TETRAZOLIUM TEST

Dwi Dinni Aulia Bakhtra, Anzharni Fajrina, Putri Ameliona

Sari


Tanaman alpukat (Persea americana Mill) merupakan salah satu jenis tanaman yang banyak digunakan secara empiris untuk terapi pengobatan oleh masyarakat. Kandungan metabolit sekunder dari daun alpukat memberikan bioaktivitas yang bervariasi. Penelitian ini bertujuan untuk melihat pengaruh pemberian ekstrak n-heksan daun alpukat Persea americana Mill terhadap pertumbuhan sel B16F0 dan menentukan aktivitas sitotoksik terhadap sel B16F0. Penentuan efek sitotoksik dan pengaruh terhadap sel B16F0 dilakukan metode Microculture Tetrazolium Test (MTT) dengan 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromida. Dari hasil penelitian yang didapatkan hasil bahwa ekstrak n-heksan Persea americana Mill mempengaruhi pertumbuhan sel B16F0, peningkatan konsentrasi uji mempengaruhi persentase jumlah sel yang hidup. Ekstrak n-heksan dari daun alpukat (Persea americana Mill) memiliki aktivitas sitotoksik dengan nilai IC50 4,246 μg/mL, yang berada dalam kategori sangat toksik. Dari hasil penelitian dapat disimpulkan bahwa ekstrak n-heksan daun alpukat Persea americana Mill mempengaruhi pertumbuhan sel dalam  kategori sangat toksik.


Kata Kunci


Persea americana Mill; sel B16F0; aktivitas sitotoksik

Teks Lengkap:

PDF

Referensi


ojs2 has produced an error Message: WARNING: Declaration of MetadataDescriptionDAO::getInsertId() should be compatible with DAO::getInsertId($table = '', $id = '', $callHooks = true) In file: /home/jurn44120/public_html/jurnalfarmasihigea.org/lib/pkp/classes/metadata/MetadataDescriptionDAO.inc.php At line: 166 Stacktrace: Server info: OS: Linux PHP Version: 7.4.33 Apache Version: N/A DB Driver: mysqli DB server version: 10.11.16-MariaDB-cll-lve

Abubakar, A. N. F., Achmadi, S. S., & Suparto, I. H. 2017. Triterpenoid Of Avocado (Persea americana) Seed and Its Cytotoxic Activity Toward Breast MCF-7 and Liver HepG2 Cancer Cells. Journal: Tropical Biomedicine, 7(5): 397-400.

Akmal, M., Indahaan, Z., Widhawati., & Sari, S. 2017. Ensiklopedi Kesehatan Untuk Umum. Yogyakarta: Ar-Ruzz Media.

Awaludin., & Gusri A. 2018. Pemberian Persea americana Mill pada pasien Hipertensi. Ilmiah Permas, 8(2):99-106.

Balafif, R. A. R., & Gunawan, E. R. 2013. Analisis Senyawa Triterpenoid Dari Hasil Fraksinasi Ekstrak Air Buah Buncis (Phaseolus vulgaris Linn). Chem. Prog, 6, (2): 56-61.

Dalimartha, S. 2008. Atlas Tumbuhan Obat Indonesia Jilid 5. Pustaka Bunda:Jakarta.

Departemen Kesehatan Republik Indonesia. 1985 .Cara Pembuatan Simplisia. Jakarta: Dapertemen Kesehatan Republik Indonesia

Dapartemen Kesehatan Republik Indonesia. 2008. Farmakope Herbal Indonesia Edisi I. Jakarta: Direktorat Jenderal Pengawasan Obat Dan Makanan

Departemen Kesehatan Republik Indonesia. 2017. Farmakope Herbal Indonesia Edisi II. Jakarta: Departemen Kesehatan Republik Indonesia.

Hendaria, M. P., Asmarajaya A. A. G. N., & Maliyawan, S. 2013. Skin Cancer. E-Jurnal Medika Udayana, 2(2): 273-289.

Ismiati, N., & Trilestari. 2014. Pengembangan Formulasi Masker Ekstrak Air Daun Alpukat (Persea americana Mill) Sebagai Antibakteri Staphylococcus aureus Untuk Pengobatan Jerawat. Pharmaciana, 4(1): 45-52.

Mardiyaningsih, A., & Ismiyati, N. 2014. Cytotoxic Activity Of Ethanolic Extract Of Persea americana Mill. Leaves On Hela Cervical Cancer Cell. Medicine Journal, 19(1): 1410-5918.

Nurhayati A.P.D., Nurlita A. & Rachmat, F. 2006. Uji Toksisitas Ekstrak Eucheuma Alvarezii terhadap Artemia Salina sebagai Studi Pendahuluan Potensi Antikanker. Akta Kimindo, 2(1): 41-46.

Prayong P., Barusrux S., Weerapreeyakul N. 2008. Cytotoxic Activity Screening of Some Indigenous Thai Plants. Fitoterapia, 79 (7): 598-601

Riswan, A. A. R. 2018. Identifikasi Metabolit Sekunder Ekstrak n-heksan dari Daun Alpukat (Persea americana) Dan Uji toksisitas Terhadap Artemia salina Leach. Makassar:Fakultas Sains dan Teknologi.

Sangeetha, K. S. S., Umamaheswari, S., Reddy, C. U. M., & Kalkura, S. N. 2016. Flavonoids: Therapeutic Potential Of Natural Pharmacological Agents. JPSR, 7(10): 3924-3930.

Widiyastuti, Y., Pratiwi, R., Riyanto S., & Wahyuono, S. 2018. Cytotoxic activity and apoptosis induction of avocado Persea americana Mill. Seed extract on MCF-7 cancer cell line. Biotechnology, 23(2): 61-67.

Yuliani, R., Santoso, B., & Sari, M. D. 2019. Cytotoxic Activity Screening of Ethanolic Extract of Longan Leaves (Dimocarpus longan), Jamaican Cherry Leaves (Muntingia calabura), and Avocado Leaves (Persea american) against T47D dan WiDr Cells. Pharmacon, 16(2): 2685-5062.




DOI: http://dx.doi.org/10.52689/higea.v16i1.550

Refbacks

  • Saat ini tidak ada refbacks.


##submission.license.cc.by-nc-sa4.footer##