Kompleks Inklusi Amlodipin Besilat – β-siklodekstrin Dengan Metode Kneading

Indra Makmur, Auzal Halim, Maria Dona Oktavia, Helvia Angraeni

Sari


Preparation and characterization of inclusion complex of amlodipine besylat with β - cyclodextrin has been done. Preparation of the inclusion complex was carried kneading method. Formed inclusion complex was characterized by X-ray diffraction, FT - IR spectrophotometer, Scanning Electron Microscopy (SEM), and the dissolution test. Data from X-ray diffraction, FT - IR, SEM can be concluded that inclusion complexes with kneading method give the best results. The dissolution efficient  results showed that the inclusion complex of amlodipine besylat - β - cyclodextrin with a kneading method increased significantly when compared with the active ingredient and the mixture of physics.

Kata Kunci


Amlodipine beylat; inclusion complex; β-cyclodextrin; disolution efficient

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Referensi


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DOI: http://dx.doi.org/10.52689/higea.v10i1.194

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