Formulasi Dan Evaluasi Stabilitas Fisik Suspensi Ibuprofen Menggunakan Kombinasi Polimer Serbuk Gom Arab Dan Natrium Karboksimetilselulosa

Rina Wahyuni, Syofyan Syofyan, Septa Yunalti

Sari


The research about formulation and evaluation of physical stability of ibuprofen suspension using arabic gom and  natrium carboxymethylcelulose as suspending agent had been done. Concentration of arabic gom and  natrium carboxymethylcelulose were 2.5 : 0.25, 5 : 0.5, 2.5 : 0.75 and 5 : 1 % for F1, F2, F3 and F4 respectinely. Evaluation of physical stability had been done  for 8 weeks, ie organoleptic, density, viscosity, volume of sedimentation, redispresion, pH, freeze thaw cycling, crystal growth and particle size distribution. Concentration of arabic gom and natrium carboxymethylcelulose had been influenced the physical stability of suspension.

Kata Kunci


Ibuprofen; Suspension; Polimer; Pulvis Gummi Arabici; Natrium Carboxymethylcelulose

Teks Lengkap:

PDF (English)

Referensi


Anief, M., (1994). Farmasetika. Yogyakarta: Gadjah Mada University Press.

Ansel, H.C. (2008). Pengantar bentuk sediaan farmasi. (Edisi IV). Penerjemah: Parida ibrahim. Jakarta: Penerbit Universitas Indonesia (UI-Press).

Aremu, O.I., & Oduyela, O.O. (2015). Evaluation of Metronidazole suspensions. African Journal of Pharmacy and Pharmacology. 9 (12), 439-450.

Departemen Kesehatan Republik Indonesia. (1995). Farmakope Indonesia. (Edisi IV). Jakarta: Departemen Kesehatan Republik Indonesia.

Gebresamuel, N., & Gebre-Mariam, T. (2013). Evaluation of suspending agent properties of two local Opuntia spp. muchilago on Paracetamol suspension. Journal of Pharmacy and Sciences. 26 (1), 23-29.

Gunawan, S.G., Setiabudy, S., Nafrialdi., & Elysabeth. (2008). Farmakologi dan Terapi. (Edisi 5). Jakarta: Balai Penerbit Fakultas Kedokteran Universitas Indonesia.

Hussein, W., Waqar, S., Khalid, S., & Naveed, S. (2009). Importance of bioavailability of drug with reference to dosage form and formulation. Journal of Pharmaceutics and Cosmetology. 2 (7), 39-44.

Kementerian Kesehatan Republik Indonesia. (2014). Farmakope Indonesia. (Edisi V). Jakarta: Kementerian Kesehatan Republik Indonesia.

Lachman, L., Lieberman, H. A., & Kanig, J. L. (1994). Teori dan praktek farmasi industri I (Edisi 3). Penerjemah: Siti Suyatmi. Jakarta: Universitas Indonesia Press.

Madjid, S., Naser, D. M., & Djavad, F. (2003). Prevention of crystal growth in Acetaminophen suspension by the use of Polyvinyl pyrrolidone and Bovine serum albumin. International Journal of Pharmacy and Pharmaceutics Sciences. 11 (3), 139-148.

Martin, A., Swarbrick, J., & Cammarata, A. (1993). Farmasi fisik jilid II (Edisi 3). Penerjemah: Joshita Djajadisastra. Jakarta: Universitas Indonesia Press.

Nep, E.I., dan Conway, B.R. (2011). Evaluation of Grewia polysaccharide gum as a suspending agent. International Journal of Pharmacy and Pharmaceutics Sciences. 3 (2), 168-152.

Panda, M., Patro, G., & Malpani, A. (2011). Formulation and evaluation of Norfloxacin suspension with β-cyclodextrin complexation. International Journal of Pharmaceutics Sciences Review and Research. 9 (1), 173-177.

Popa, L., & Ghica, M.V. (2011). Ibuprofen pediatric suspension design and optimized by responce surface. Journal of Physical and Colloidal Chemistry. 59 (4), 500-506.

Rowe, R.C., Sheskey, P.J., & Quinn, M.E. (2009). Handbook of pharmaceutical excipients, (6th ed). Washington D.C : Pharmaceutical Press and American Pharmacists Association.

Sana, S., Rajani, A., Sumedha, N., & Mahesh, B. (2012). Formulation and evaluation of taste masked oral suspension of Dextromethorphan hydrobromide. International Journal of Drug Development and Research. 4 (2), 159-172.

Shah, K., Shrivastava S. K., & Mishra, P. (2014). Formulation and evaluation of supension: Mefenamic acid produgs. Journal of Pharmacy and Sciences. 27 (4), 917-923.

Tjay, T. H., & Rahardja, K. (2007). Obat-Obat Penting, Khasiat, Penggunaan, dan Efek sampingnya (edisi IV). Jakarta: PT. Elex Media Komputindo Kelompok Kompas-Gramedia.

Voight, R. (1994). Buku Teknologi Farmasi. (Edisi 5). Penerjemah: Soendani Noerono. Yogyakarta: Universitas Gajah Mada.




DOI: http://dx.doi.org/10.52689/higea.v9i1.158

Refbacks

  • Saat ini tidak ada refbacks.


##submission.license.cc.by-nc-sa4.footer##

https://montes.da.upm.es/

https://csdmm.da.upm.es/

slot gacor hari ini

sekumpul faktaradar puncakinfo traffic idTAKAPEDIAKIOSGAMERLapakgamingBangjeffSinar NusaRatujackNusantarajackscarlotharlot1buycelebrexonlinebebimichaville bloghaberedhaveseatwill travelinspa kyotorippin kittentheblackmore groupthornville churchgarage doors and partsglobal health wiremclub worldshahid onlinestfrancis lucknowsustainability pioneersjohnhawk insunratedleegay lordamerican partysckhaleej timesjobsmidwest garagebuildersrobert draws5bloggerassistive technology partnerschamberlains of londonclubdelisameet muscatinenetprotozovisit marktwainlakebroomcorn johnnyscolor adoactioneobdtoolgrb projectimmovestingelvallegritalight housedenvermonika pandeypersonal cloudsscreemothe berkshiremallhorror yearbooksimpplertxcovidtestpafi kabupaten riauabcd eldescansogardamediaradio senda1680rumah jualindependent reportsultana royaldiyes internationalpasmarquekudakyividn play365nyatanyata faktatechby androidwxhbfmabgxmoron cafepitch warsgang flowkduntop tensthingsplay sourceinfolestanze cafearcadiadailyresilienceapacdiesel specialistsngocstipcasal delravalfast creasiteupstart crowthecomedyelmsleepjoshshearmedia970panas mediacapital personalcherry gamespilates pilacharleston marketreportdigiturk bulgariaorlando mayor2023daiphatthanh vietnamentertain oramakent academymiangotwilight moviepipemediaa7frmuurahaisetaffordablespace flightvilanobandheathledger centralkpopstarz smashingsalonliterario libroamericasolidly statedportugal protocoloorah saddiqimusshalfordvetworkthefree lancedeskapogee mgink bloommikay lacampinosgotham medicine34lowseoulyaboogiewoogie cafelewisoftmccuskercopuertoricohead linenewscentrum digitalasiasindonewsbolanewsdapurumamiindozonejakarta kerasjurnal mistispodhubgila promoseputar otomotifoxligaidnggidnppidnggarenaoxligaiaspweb designvrimsshipflorida islandkatsu shirotasty bonanza sebagai representasi hedonisme digitalvalidasi rasio risiko dan imbalan pada slot progressive multiplieranalisis psikometri player satisfaction pada sistem jackpot virtualanalisis sistemik terhadap mekanisme bonus berlapis pada pg soft gameseksaminasi struktur reward variabel pada slot candy themed moderninterpretasi teori flow dalam pengalaman bermain slot pragmatic playinvestigasi efek audio stimulus terhadap fokus pemain slotpendekatan statistik inferensial dalam evaluasi rtp game onlinerekonstruksi arsitektur gameplay dalam slot interaktif berbasis eventsintesis interaksi visual dan probabilitas dalam slot digital era kontemporerstudi komputasi terhadap efisiensi rng dalam simulasi slot digitaltelaah akademik terhadap evolusi slot online dari mekanis ke digitalfenomenologi pengalaman bermain dalam slot bertema fantasi modernintegrasi teknologi animasi real time pada game pg soft generasi terbarukonseptualisasi desain karakter pada starlight princess dalam perspektif media digitalmodel prediktif variansi slot berbasis analisis big data gamingpendekatan neurogaming terhadap respons dopamin pada sistem reward slotperspektif antropologi digital terhadap popularitas tema mitologi dalam slot onlinerefleksi ekonomi mikro dalam struktur hadiah slot online kontemporerrekonstruksi sistem bonus buy feature sebagai evolusi monetisasi gamesimulasi probabilistik kombinasi simbol pada sugar rush menggunakan analisis statistikstudi komparatif freespin mechanism antara provider pg soft dan pragmatic playanalisis temporal frekuensi scatter pada slot volatilitas menengahdekonstruksi narasi heroik dalam gates of olympus sebagai simbol gamifikasi moderneksaminasi struktur multiplier progresif pada game zeus themed slotevaluasi interaksi player interface terhadap durasi bermain pengguna aktifinterpretasi visual culture dalam desain slot asia themed pg softmetodologi evaluasi fairness algorithm dalam slot berbasis rngobservasi desain interaktif terhadap tingkat engagement pemain kasino digitaloptimalisasi experience loop pada game sweet bonanza melalui ux engineeringpendekatan sistem kompleks terhadap ekonomi virtual slot onlinestudi empiris tentang persepsi risiko dalam slot high variance