Sekolah Tinggi Ilmu Farmasi (STIFARM) Padang ISSN: 2541-3554
Jurnal Farmasi Higea Sekolah Tinggi Ilmu Farmasi Padang

Karakterisasi Kompleks Inklusi Telmisartan – Β-Siklodekstrin Dengan Metode Penggilingan Bersama

Indra Makmur, Henni Rosaini, Wahyuni Eka Putri, Maria Dona Octavia

Sari

Telmisartan merupakan obat antihipertensi dan diklasifikasikan ke dalam BCS kelas II,  yang memiliki kelarutan rendah dalam air dan permeabilitas tinggi. Penelitian ini bertujuan untuk mengkarakterisasi, meningkatkan kelarutan serta laju disolusi telmisartan dengan cara pembentukan kompleks inklusi telmisartan - β-siklodekstrin. Pembuatan kompleks inklusi dilakukan dengan metoda penggilingan bersama dengan rasio 1:1 molar dengan variasi waktu penggilingan formula 1 selama 1 jam, formula 2 selama 2 jam. Kompleks inklusi dan campuran fisik dikarakterisasi dengan difraksi sinar X, Differential Scanning calorimetry (DSC), spektrofotometri inframerah, dan disolusi. Hasil pembentukan kompleks inklusi telmisartan - β-siklodekstrin dapat meningkatkan laju disolusi telmisartan. Persentase kadar terdisolusi pada menit ke-60 untuk  telmisartan, campuran fisik, formula 1 dan formula 2 berturut-turut adalah 2,5953 %, 2,5257 %, 61,1295 dan 61,2077 %. Formula terbaik ditunjukkan oleh formula 2 dengan waktu penggilangan 2 jam.

Kata Kunci

Telmisartan; β-siklodekstrin; Kompleks Inklusi; Penggilingan bersama

Teks Lengkap:

PDF

Referensi

Bunaciu, A. A., UdriÅŸtioiu, E. gabriela, & Aboul-Enein, H. Y. (2015). X-Ray Diffraction: Instrumentation and Applications.

Critical Reviews in Analytical Chemistry, 45(4), 289–299. https://doi.org/10.1080/10408347.2014.949616

Dachriyanus. (2004). Analisis Struktur Senyawa Organik Secara Spektroskopi. Padang : LPTIK Universitas Andalas.

Deppe, S., Böger, R. H., Weiss, J., & Benndorf, R. A. (2010). Telmisartan: A review of its pharmacodynamic and pharmacokinetic properties. Expert Opinion on Drug Metabolism and Toxicology, 6(7), 863–871. https://doi.org/10.1517/17425255.2010.494597

Iqbal, Z. (2018). Evaluation of the effect of co"’grinding on dissolution rate of poor water soluble drug (clarithromycin). MOJ

Drug Design Development & Therapy, 2(4), 232– 237. https://doi.org/10.15406/mojddt.2018.02.00052

Jagtap, S., Magdum, C., Jadge, D., & Jagtap, R. (2018). Solubility enhancement technique: A review. Journal of Pharmaceutical Sciences and Research, 10(9), 2205– 2211.

Leyva-porras, C., Cruz-alcantar, P.,spinosa-sol, V., & Saavedra-leos, M. Z. (2019). Application of Diff erential Scanning Calorimetry ( DSC ) and Modulated Di ff erential Scanning. Polymers, 12(5), 1–21.

Loftsson T & Brewster, M. (1996). Pharmaceutical applications of siklodekstrins, drug solubilization and stabilization. J. Pharm. Sci, 85(10), 1017- 1024.

Lopes, C. de C. A., Limirio, P. H. J. O., Novais, V. R., & Dechichi, P. (2018). Fourier transform infrared spectroscopy (FTIR) application chemical characterization of enamel, dentin and bone. Applied Spectroscopy Reviews, 53(9), 747–769. https://doi.org/10.1080/05704928.2018.1431923

Jug, M., & Mura, P. A. (2018). Grinding as solvent-free green chemistry approach for cyclodextrin inclusion complex preparation in the solid state. Pharmaceutics, 10(4). https://doi.org/10.3390/pharmaceutics10040189

Patel, K., Patel, A., Dave, J., & Patel, C. (2012). Absorbance correction method for estimation of telmisartan and metoprolol succinate in combined tablet dosage forms. Pharmaceutical Methods, 3(2), 106–111. https://doi.org/10.4103/2229-4708.103891

Patil, J. S., Kadam, D. V., Marapur, S. C., & Kamalapur, M. V. (2010). Inclusion complex system; a novel technique to improve the solubility and bioavailability of poorly soluble drugs: A review. International Journal of Pharmaceutical Sciences Review and Research, 2(2), 29–34.

Print, I., Online, I., Semalty, A., Tanwar, Y. S., College, B. N. P. G., & Udaipur, P. (2013). World Journal of Pharmaceutical Sciences Preparation and Characterization of Cyclodextrin Inclusion Complexes for Improving Solubility and Dissolution of Nimesulide Department of Pharmaceutical Sciences , H . N . B . Garhwal University , Srinagar Garhwa. January.

Rowe, R. C., Sheskey, P. J., & Quinn, M.E. (2006). Handbook Of Phamaceutical Excipients (6thed). London : Pharmaceutical Press and American Pharmacist Association.

Savjani, K. T., Gajjar, A. K., & Savjani, J. K. (2012). Drug Solubility: Importance and Enhancement Techniques. ISRN Pharmaceutics, 2012(100 mL), 1–10. https://doi.org/10.5402/2012/195727

Setiabudi, A., Hardian, R., & Muzakir, A. (2012) . Karakterisasi Material; Prinsip dan Aplikasinya dalam Penelitian Kimia. Bandung : Universitas Pendidikan Indonesia press.

Singh, A., Jha, K. K., Mittal, A., & Kumar, A. (2013). RESEARCH ARTICLE A Review on : Telmisartan. 2(1), 160–175.

The Department Of Health. (2009). British pharmacopoeia (4th ed). Geneva: World Health Organization.

The Ministry Of Health, Labour and Welfare. (2016). The japanese pharmacopeia (17th ed). Japan: The Minister Of Health, Labour and Welfare.

Trends, F., Cyclodextrin, O. F., Technique, S., Improving, F. O. R., Bioavailability, O., Poorly, O. F., & Drugs, S. (2016). International Journal of Pharmaceutical Research and Bio-Science Superior Technique for Improving Oral Bioavailability of Poorly. 5(3), 236– 265.

Yáñez, C., Cañete-Rosales, P., Castillo, J. P., Catalán, N., Undabeytia, T., & Morillo, E. (2012). Cyclodextrin inclusion complex to improve physicochemical properties of herbicide bentazon: Exploring better formulations. PLoS ONE, 7(8), 1–11. https://doi.org/10.1371/journal.pone.0041072

Zaini, E., Fitriani, L., Effendy, S., Noviza, D., & Halim Auzal. (2017). Preparation and characterization of solid dispersion telmisartan – hydroxypropyl methyl cellulose (HPMC) E5 LV by Co-Grinding Method. Orient. J. Chem., Vol. 33(2), 873-878.

DOI: http://dx.doi.org/10.52689/higea.v12i2.291

Refbacks

  • Saat ini tidak ada refbacks.
Creative Commons License
Karya ini dilisensikan di bawah Lisensi Internasional Creative Commons Atribusi-NonKomersial-BerbagiSerupa 4.0.

e-ISSN: 2541-3554 | p-ISSN: 2086-9827