Peningkatan Laju Disolusi Sistem Dispersi Padat Ibuprofen – PEG 6000

Auzal Halim, Elvi Rahma Yulisman, Erizal Zaini

Sari


It has done research on increasing the dissolution rate of solid dispersion system Ibuprofen with polymer Polyethylenglycols 6000 (PEG 6000). Solid dispersion system prepared by melting method with a ratio of raw materials Ibuprofen - PEG 6000, namely : 6:4, 7:3, 8:2, and 9:1. As a comparison was made with the physical mixture of the same composition. The powder mixture of physics and solid dispersion system properties of solids characterized by spectroscopic analysis, SEM analysis, DTA analysis, and X-ray diffraction analysis. Dissolution test method is determined by a basket. The results showed that the powder solid dispersion system can improve the physicochemical properties of Ibuprofen. Dissolution profiles showed that the 7:3 solid dispersion system powder in the 45th minute to increase the dissolution rate compared to the powder mixture of physics.

Kata Kunci


Solid Dispersion System, ibuprofen, PEG 6000

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PDF (English)

Referensi


Ansel, H. C. (1989). Pengantar Bentuk Sediaan Farmasi. (Edisi 4). Penerjemah : Farida Ibrahim. Jakarta : Universitas Indonesia Press.

Basavoju, S. & Bostrom, S. P. V. (2007). Indomethacin – Saccharin Cocrystal : Design, Synthesis, and Preliminary Pharmaceutical Characterization. Pharm Res, 25, (3), 530 – 540.

Basavoju, S. & Bostrom, S. P. V. (2007). Indomethacin – Saccharin Cocrystal : Design, Synthesis, and Preliminary Pharmaceutical Characterization. Pharm Res, 25, (3), 530 – 540.

Chiou, W. L. & Riegelman, S. (1971). Pharmaceutical Applications of Solid Dispersion System. J Pharm Sci, 60 (9), 1281 – 1302.

Departemen Kesehatan Republik Indonesia. (1979). Farmakope Indonesia (Edisi III). Jakarta.

Garekani, H. A., Sadeghi, F., Badice, A., Mostafa, S. A., & Rajabi, A. R. (2001). Crystal Habit Modifications of Ibuprofen and Their Phsycomechanical Characteristics. Drug, Dev, and Ind Pharm, 27 (8), 803 – 809.

Garekani, H. A., Sadeghi, F., Badice, A., Mostafa, S. A., & Rajabi, A. R. (2001). Crystal Habit Modifications of Ibuprofen and Their Phsycomechanical Characteristics. Drug, Dev, and Ind Pharm, 27 (8), 803 – 809.

Llyod, G. R., Craig, D. Q. M., & Smith, A. (1997). An Investigation Into The Melting Behavior of Binary Mixes and Solid Dispersion of Paracetamol and PEG 6000. J Pharm Sci, 86 (9), 991 – 996.

Llyod, G. R., Craig, D. Q. M., & Smith, A. (1997). An Investigation Into The Melting Behavior of Binary Mixes and Solid Dispersion of Paracetamol and PEG 6000. J Pharm Sci, 86 (9), 991 – 996.

Save, T., & Venkitachalam, P. (1992). Studies on Solid Dispersion of Nifedipin. Drug, Dev, and Ind Pharm, 18 (15), 1663 – 1679.

Shargel, L., & Yu, A. B.C. (2005). Biofarmasetika dan Farmakokinetika Terapan. (Edisi 2). Penerjemah : Fasich. Surabaya : Universitas Airlangga Press.

The United State Pharmacopeial Convention. (2007). The United State Pharmacopeia. New York.

Tjay, H. T., & Rahardja, K. (2007). Obat – Obat Penting. (Edisi 6). Jakarta : PT. Elex Media Komputindo Kelompok Kompas - Gramedia.

Wade, A., & Weller, P. J. (1994). Handbook of Pharmaceutical Excipient (2th ed). London : The Pharmaceutical Press.

Zaini, E., Sumirtapura, Y. C., Soewandhi, S. N., & Halim, A. (2010). Identifikasi Interaksi Fisika antara Trimetoprim dan Sulfametoksazol dengan Metode Kontak Kofler dan Reaksi Kristalisasi. Majalah Farmasi Indonesia, 21 (1),32 – 39.




DOI: http://dx.doi.org/10.52689/higea.v5i2.83

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